ارتباط خانوادگي ليپيدهاي سرمي و نقش تغذيه مطالعه قند و ليپيد تهران

Familial aggregation of serum lipids and the role of nutrition: Tehran Lipid and Glucose Study

lntroduction: The role of gene and environment in the pathogenesis of abnormal lipid profile is still the case of controversy. To clarify the importance of certain parental risk factors associated with the lipid profiles of children and adolescents, we conducted this cross-sectional population based study in district-13 in the east of metropolitan Tehran. Materials and Methods: One hundred thirteen eligible families comprising 455 subjects (including 229 offspring aged 5-25 years) were enrolled into the study. Anthropometric data were measured by a standard protocol. For the measurement of lipid profiles, venous blood was obtained in the morning, after the subjects had fasted 12-U hours overnight. Dietary intakes were assessed by means of a two-day dietary recall questionnaire. Results: The chances of having elevated serum total cholesterol (TC) were higher in sons of fathers with high cholesterol intake (OR=3.1; CI=1.1-9.2) and mothers with high saturated fatty acids (SFA) intake (OR=3.4; CI=1.1-10.8). Positive correlation was seen between energy intake of fathers and serum TC of their daughters (r=0.34, p<0.01), between SFA intake of fathers and serum trigelycerides (TGs) of their sons (r=0.29, p<0.01) and between mothersʹ body mass index (BMl) and daughtersʹ serum TGs (r=0.23, p<0.03). The chances of having low serum high-density lipoprotein- cholesterol (HDL-C) were lower in sons of mothers with high carbohydrate intake (OR=11.0; CI=2.8-42.8) and mothers with high serum HDL-C (OR=6.8; CI=1.7-27.0). The chances of having elevated serum low-density lipoprotein-cholesterol (LDL-C) were higher in sons of fathers with high SFA intake (OR=4.5; CI=1.4-14.3); and sons of mothers with high serum TGs (OR=6.1; 1.3-29.0) and of mothers with high cholesterol intake (OR=4.3; CI=1.2-15.2). Conclusion: The results indicate independent associations between diet contents, the lipid profiles of parents and those of their offspring as well as between lipid profiles and diet contents among spouses.