بررسي ميزان B21 و اسيد فوليك در بيماران با آفت عود كننده ي دهان

A STUDY OF B12 AND FOLIC ACID LEVELS IN PATIENTS WITH RECURRENT APHTOUS STOMATITIS

Recurrent Aphtous stomatitis is the most prevalent cause of mouth sores, and the causative factors are not completely clear. Previous studies show that 10 - 20% of patients suffer from hematological disturbances , especially reduction of iron, serum ferritin , folate or B12 levels.The present investigation attempts to study the above mentioned causes in patients with certain genetic and environmental conditions. For this purpose, 50 patients with aphthous stomatitis were selected and another 52 patients refering to dermatology centers for other reasons were selected as a reference group . All of the patients including those in the reference group had not been treated with iron, folic acid, or B12 in the six months preceding this study. The B12 and serum folic acid levels were measured using a 5cc fasting blood sample. The results showed a reduction of 207.18mg in B12 levels in the study group which was 221.272 mg in men and 22.494 mg in women. The reduction of folic acid levels was 2.003 mg in the study group ; 3.871 mg in men and 1.084 mg in women. The results obtained from the tests were analyzed by statistical method of variance of the t.Test , and in both cases a significant variation was detected. Also , on the whole, the hematologic disturbances were 64% in patients, and 28% in the control group , which shows a significant statistical difference, and indicates that B12 and folic acid reduction have a causal effect on the occurrence of the ahpthous ulcers, thus treating patients with B12 and folic acid can to some extent be effective in the treatment of recurrent aphthous stomatitis.