بررسي اثرات درماني فلوكستين بر سندرم ملال پيش از قاعدگي

Introduction: According to the high prevalence of PMS, and severe function and distress it causes, itʹs important to compare the various treatments which are available for the disorder. Method and materials: We chose 450 18-year-old single female students from the Mashhad Medical University, and asked them to fill the inventories which were prepared based on the DSM-IV criteria for PMS. They were settled at some dormitories around the city. 409 of them answered the questions. PMS was diagnosed in 84 cases, using the inventories; and clinical and structurized interviews were performed with them . We divided them into two groups randomly. Some received fluoxetine ( 20 mg / day ) and others took multivitamin plus mineral capsules as placebo (one capsule a day for 3 months). This survey was a randomized and controlled clinical trial. Results: The improvement rate in the fluoxetine treated group was statistically significant higher than the placebo treated group (P <0.01 ). The symptoms, which best responded to drugs were depression, emotional, lability, anger, appetite changes, self-control disability, disinterest in usual activities, concentration difficulties, and sleep disturbances. Conclusion: Considering the cost benefits and availability of fiuoxatine and its good effect on PMS (which has been proved in different researches), this drug with dose of 20mg/day is believed to be one of the best medications for PMS management.