بررسي اثر مصرف مزمن خوراكي آلومينويم هيدروكسيد بر تست تحمل گلوكز در موش صحرايي نر RAT

The Effect of Oral High Aluminium Intake on F.B.S. and G.T.T. in Rat

Aluminium is one of the most abundant elements in the earth crust and enters the body through drinking water, Industrial use, nutrients and antiacids. Aluminium poisoning causes wide range of disorders, and decrease the release of neurotransmitters through inhibition of Voltage Dependent Calcium Channels(VDCCS). The role of calcium on insulin release and its secretion has been considering. The experiments were performed to study the effect of high aluminium intake on male rats G.T.T. ( n=11). At first the animals were weighted and their F.B.S. tested. After consumption of oral glucose, their G.T.T. were also tested. Animals consumed a diet containing aluminium (16.2g/Kg diet) for 50 days. At the end of the experiment, F.B.S. and G.T.T. again were measured. The results show that the first F.B.S. and G.T.T. were 127± 5.4 and 116.32±2.74 mg/dl. After consuming a diet containing aluminium, F.B.S. and G.T.T. were 99.9±1.84 and 140.8±3.36 mg/dl. This study show that high aluminium intake increases G.T.T. and decreases the body weight in the rats. Further studies are needed to show the exact mechanism of aluminium ion on blood suger.