نقش ميزان روي در بروز تشنج و تعيين ميزان روي هيپوكامپ در موشهاي صحرايي

EFFECTS OF DIETARY ZINC STATUS ON SEIZURE SUSCEPTIBILITY AND HIPPOCAMPAL ZINC CONTENT OF RATS

The effects of dietary zinc status on the development of convulsive seizures and zinc concentration in hippocampal area were studied in three groups of rats that receiving zinc adequate, zinc load and usual water diet. Hippocampal zinc level was determined by an atomic absorption spectrophotometer. Ninteen male rats were randomly assigned to three deitary groups and assesed in ten weeks. Seizure was induced in rats by administration intraperitoneal injection of lithium chloride and pilocarpine. Differences were tested for statistical significance with analysis of variance (ANOVA) followed by other tests. Seizure susceptibility of mouse was decreased by zinc loading. Zinc loading was accompanied by a marked increase in hippocampal zinc content. These results suggest that zinc could have preventive effect on the devefopment of seizures and hippocampal zinc may pfay an important rofe in the patophysiology of convulsive seizure of epilepsy.