بررسي پاسخ درماني انواع مختلف اختلال وسواسي - جبري به فلوكستين

A Study on the Effectiveness of Fluoxetine on Different Clinical Subtypes of Obsessive-Compulsive Disorder

Background and Objectives: The clinical presentation of obsessive - compulsive disorder (OCD) is highly heterogeneous. Fluoxetine has been known as an effective drug in the frealnie rt of OCR but there is no convincing information about the effect of the agent on the subtypes a the illness. This study was conducted to investigate the effectiveness of fluoxetiue in treniIiii, three subtypes of OCI) (washing, obsessive thoughts, and checking). Materials and Methods: One hundred OCD patients referred to Rani hospital and two private clinics in Tabriz, were selected randomly. They were examined by f)Sti1-IV-"R hissed interview. Physical and substance related disorders were excluded, l hey were assigned to three groups : washing , obsessive thoughts and checking. All groups completed the Yale - Itrl vii scale before and two months after receiving fluoxetine with average doses between ,10-SO stag Idly. Two scores (before and after treatment) were compared and analyzed with statistical paired t - test. Results: The results showed that all subjects (regardless of their subtypes) significantly responded to fluoxetine (p < 0.001). Washer subjects and the patients with obsessive thoughts showed better response to the drug (p-values were 0.000 and 0.001, respectively). Conclusion: There was a significant difference between checkers and the other groups of OCD patients in response to fluoxetine therapy and the checker group showed no significant response. This finding can help physicians in treatment planning of OCD patients.