بررسي فتوتيپهاي مختلف كلاس يك HLA در بيماران نوع II مراجعه كننده به مركز ديابت يزد

Diabetes mellitus is one of the most common metabolic disorders, Its prevalence is estimated to be about 1-2 percent in the general population; of which 90 percent are NIDDM cases ( Type II Diabetics). Diabetes mellitus is related to genetic-environmental risk tactors.The correlation between diabetes mellitus typel and MHC has been documented (DR3 , DR4).Genetics plays an important role in type 11 Diabetes Mellitus. The concordance rate for Diabetes Mellitus in monozygote twins is 90 - 100% , but its exact mechanism of inheritance is unclear . It is probable that more than one mechanism contribute to its occurrence . There is no documented relationship between Diabetes Mellitus type II and MHC , however some investigators suggest that NIDDM is also related to various phenotypes of H LA . In this descriptive-cross sectional study , 46 cases and 53 controls were simply randomized , and then phenotype of H LA class I was determined in both the groups. The difference between the types of phenotype(HLAclass 1) was examined in both the groups . Results showed that HLA CW1(p=0.027), B35(p=0.02) and B22(p=0.027) were more in the control group while HLA BW4(P=0.001) was more in the case group . The relationship of NIDDM and HLA BW4 antigens in Yazd suggests that the MHC or other genes on chromosome 6 play a role in NIDDM in Yazd province.