علل ميكروبي كوله سيستيت حاد و آنتي بيوتيك هاي موثر بر آن در بيماران بستري در بيمارستان شفيعيه ي زنجان در طي سال هاي 80-1375

Common microbial agents and effective antibiotics in acute cholecystitis in Zanjan Shafieh hospital from 1997 to 2002

Background: Microbial infection is the most common cause of acute cholecystitis and also its complications. Therefore determining the kind of microbes in the gallbladder bile and recognizing their sensitivity to different antimicrobial agents is crucial for its proper management. The present study was carried out in patients who were admitted and operated on for acute cholecystitis in Zanjan Shafieh hospital. Materials and Methods: In this descriptive study (The existing data) the files of patients who were admitted and operated for acute cholecystitis and also had results of bile culture and antibiogram were used from the records of Shafieh hospital from 1997 to 2002. The data were analysed by descriptive statistics. Results: Amongst sixty patients who had the results of bile cultures in their files, 42(70%) cases had positive and 18 (30%) cases had negative microbial cultures. The most common organisms found in the cultures were E.coli (54.8%), Staphylococus aureus (14.3%), klebsiella (9.5%) and enterobacter (9.5%) respectively. The most effective antibiotics in this study were Amikacin (69.5%), Gentamicin (47.6%), and Nalidixic Acid (42.9%). Conclusion: Positive culture of bile can be found in most cases of acute cholecystitis. Since Amikacin was the most effective antibiotic in cases of acute cholecystitis, it is recommended to be used in these cases as the first choice.