مقايسه سطوح سرمي هورمونهاي تيروييدي و تيروتروپين در افراد طبيعي و بيماران دياليزي قبل و بعد از پيوند كليه و ارتباط آنها با عملكرد كليه پيوندي

THYROID HORMONE LEVELS BEFORE AND AFTER RENAL TRANSPLANTATION IN DIALYSED AND NORMAL PATIENTS AND THEIR RELATIONSHIP WITH RENAL GRAFT FUNCTION

Chronic renal failure is one of the causes of euthyroidism which is associated with some abnormalities in thyroid hormone metabolism. Although dialysis does not significantly affect these abnormalities, but renal transplantation leads to improve the conditions. In this study, first serum levels of thyrotropin and thyroid hormones and triiodothyronine resin uptake (T3 up) were measured in 30 patients under dialysis and compared with 40 persons from the control group. After renal transplantation the patients were subdivided in to two group: 21 patients had optimal primary graft function (group I) and 9 patients had delayed graft function (group II). All patients received maintainence therapy with prednisilone, aziothoprine and cyclosporine, and thyroid indices were measured in them. In dialysis patients thyroid parameters were in the normal range, but compared with the control, mean levels of thyroid hormones were low and T3 uptake high however no changes could be observed in the levels of thyrotropin. Ten days after graft, reduction. in the levels of thyrotropin and thyroid hormones and elevation of T3 uptke were found in both the groups. The hormone alterations in group II were more than in group I. On the 30th day after graft, changes in group I reached normal levels and comparing with pregraft conditions those of before a marked improvement was noticed, but comparing with the control, the levels of free and total triiodothyronine and total thyroxine were still low. In the group II, the levels of free and total thyriod hormones were lower than those of befor opration and comparing with the control, decreased levels of thyroid hormones and elevation in the T3 Up were observed. Our studies demonstrated that there existed a relationship between the levels of thyroid hormones and function of the transplanted kidney and this relationship was more significant as regards thyroxine and triiodothyronine.