مقايسه اثر درماني ريباويرين باو بدون ايمنوگلو بولين وريدي در درمان تب خون ريزي دهنده كريمه -كنگو CCHF>> <<

A comparative study on the effect of ribaverin with and without IVIG (Intravenous imuneglobuliu) in treatment of Crimean- congo hemorrhagic Fever(CCHF)

Background and purpose: In early 2001 an epidemyic of CCHF occurred in sfahan province of IRAN. According to some reports IVIG may be useful some cases of CCHF. The aim of this study was to compare the standard regimen of oral Ribavirin with or without IVIG in CCHF patients. Materials and methods : 40 proven CCHF patients were included in the study, %30 (12 patients) were administerad ribaverin plus IVIG (case group) and %70 (28 patients) took ribaverin alone(control group). The clinical parameters of all patients were followed up for 8 weeks. Results: The mean duration for disappearance of fever and other clinical symptoms were 4.6 and 5 days in case and control groups respectively(p= 0.27). The mean time for WBC and liver function tests(LFT) normalization were 3.6 and 5.8 and 3.9 and 7.5 days in case and control groups respectively)p= 0.002) and (p=0.001). there was no significant difference in mortality rate. Conclusion: Although IVIG administration declined the duration of the dizare and caused earlier improvement in clinical and para- clinical data, it seems that it did not exert any significant effect on outcome of the disease.