بررسي اثر آسپرين بادوز پايين در پيشگيري از پراكلامپسي در پرايمي پارها

Evaluation of the effect of low doses aspirin in prevention of pre-eclampsia and primipara

Background and purpose: Hypertension during pregnancy is one of the three main causes of maternal mortality which is followed by bleeding and infection. In an effort to prevent pre-eclampsia, different ways are used. The drugs which are used are aspirin and antioxidants. Aim of this study has been to evaluate the role of administration of aspirin in preventing pre-eclampsia in the patients referring to hazrat fatemeh zahra prenatal clinic from oct. 2001 to the end of may 2002. Materials and methods: This study is a randomised double blind clinical trial done on two groups: primiparas and single para on their 13`h to 320h weeks of gestational period. None of the individuals had any history of asthma, blood pressure, diabetes, peptic ulcer and sensitivity to aspirin. All of 537 persons under study, excluding 48, had complete cooperation. Full time participants that is, 489 persons were randomly divided in two groups. Case group (252 persons) received placebo and the control group (237 persons) were given aspirin. All participants of two groups on their routine referring to the prenatal clinic were tested for blood pressure, protein uria and edema. Both groups were matched for age. For statistical analysis, X2, CL and ODDS ratio were performed. Results : Occurrence of pre-eclampsia was not significant between these two groups. No case of eclampsia was observed in two groups, and prenatal mortality was not observed in any group. Conclusion: It seems that, low dose administration of antibiotic in primipara females will be effective in preventing pre-eclampsia, eclampsia, preterm delivery, under 2500 grams birth weight and prenatal mortality. Study on the use of other prophylactic drugs and study on the exact pharmacokinetic effect of aspirin is recommended.