بررسي پارامترهاي هماتولوژيك و سطح هموگلوبين A2 و F در والدين بيماران مبتلا به تالاسمي ماژور در بيرجند در سال 1381

Study of the Hmatolagio Parameters and F and A2 Hemogloblin in Parents of Patients Sufferring From Major Thalassemia in Birjand in 1381 (2002)

Thalassemias are the most common disorders in Hemoglobin production characterized by a reduction in Hemoglobin synthesis . With different genetic characteristics in each society , the carriers may experimentally have different phenotype characteristics. This research was conducted to determine the conditions - of experimental findings in the parents of infants sufferring from major thalassemia . 42 parents were selected to be studied in this descriptive study as for their CBC , MCV , MCH, the number of Hb , RBC , and F and A2 Hemoglobin; 2 ml blood was taken from each and put in vials containing K3EDTA for CRC by means of ABX cell counter and Hemoglobin electrophoresis with cellulose acetat in alkaline PH and sent to laboratory . MCV lower than 80 ft , MCH lower than 27 pg and HBA2 higher than 3.5% were respectively considered as major disorders in CBC and Hemoglobin electrophoresis . In all cases , MCV , MCH and HBA2 were absolutely different from the normal range; the reference ranges for MCV and MCH are 65-73.7 and 17.7-24pg respectively . RBC was higher in 64.3% and lower in 33.3% than the normal range (0.8%-1.4%). The differences observed in this study may be attributed to the variety of genetic mutations especially to the rather high number of mutated genes in Iran ; this implies further research in other geographical areas.