مقايسه فعاليت مهاري تريپيسين در سرم بيماران هيپرتيروييدي و گروه شاهد Euthyroid( )

The Comparison of Serum Trypsin Inhibitory Capacity( TIC )in Serum Hyperthyroid Patients with Control Group(Euthyroid)

inhibitors ( serpin ).There are many reports in litreture Alpha-l-AntiTrypsin (alpha l-AT) is an inhibitory al-Protease, and belongs to complex protein of glycoprotein type. From the activity point of view, it belongs to Seiren protease concerning a decrease in the amount of Alpha l -AT in patients with emphysema, skin disorders, adult liver disease, hypothyroidism,and so on . In hypothyroidic patients along with a decrease in the amount of T3 , there is a significant decrease in the amount of Alpha l- AT and consequently in the amount of TIC.Therefore , it can be expected that , in hyperthyroidic an increase in the amount of T3 results in an increase in the amounts of Alpha l- AT and T1C. In this study , changes in TIC in hyperthyroidic patients in comparison with a control group was investigated. Measurements were performed on 72 samples , and by using T- test and determination of correlation coeffiecint,the above mentioned changes were analyzed . The results showed that TIC in hyperthyroidic patients ( n= 42 ) had increased in comparison with the control group ( n = 30 ), ( n = 42 , TIC = 2.54 ± 0.414 mg/ml Vs n= 30 ,TIC= 1.87 ± 0.29 mg/ml). It was observed that in hyperthyroidic patients, there is a positive correlation between the amounts of T3 and TIC (r = 0.71 , p < 0.0001). Therefore, it can be concluded that trypsin inhibitory capacity and Alpha l- AT concentration had increased in hyperthyroidic .