تعيين آنتي ژن اختصاصي پروستات PSA بيشتر از 4NJ/MI مراجعه كننده به كلينيك ارولوژي در مقايسه با بيماران بستري در بخش قلب

Background and aim: Prostate cancer is the most prevalent cancer in men and is the second cause of menʹs death due to cancer in the world. This form of cancer usually has no specific sign and can have definitive treatment if diagnosed in early stage. The easiest and most sensitive test for prostate cancer is serologic test for prostate specific antigen (PSA). Since this test has 43% predictive value and 67% sensitivity for PSA of more than 10 ng/mg, it is the first diagnostic method for the screening of prostate cancer. The aim of this study was to find out the prevalence of PSA>4ng/ml. Methods: In this study a group of 120 patients over 50 years old with urinary problems (group A) referred to urology clinic of Kashani hospital compared with a group of 120 men over 50 years old with no urinary problems hospitalized in cardiology ward in Hajar hospital (group B). Blood sera from each group were collected and a questionnaire for each patient was completed. An ELISA test was carried out using IEMA WELL kit. The results then were statistically analyzed using Chi-square test. Results: The prevalence of PSA>4ng/ml was 19.2% and 8.3% in group A and B respectively (P<0.05). Further, there were direct relationships between PSA>4ng/ml and factors such as age, number of children and the severity of urinary blockage. Due to low information we could not find relationship between familial history of prostate cancer, BPH treatment and the pervious vasectomy. Besides there were no significant relationships between cigarette smoking or bone pain and PSA>4ng/ml. Conclusion: Based on the results of this study a screening program for testing PSA>4ng/ml in men over 50 years old especially for those with urinary problems is recommended.