بررسي وضعيت هموديناميك بيماران در بيهوشي عمومي با هالوتان - فنتانيل (بدون استفاده از N2O )

A COMPARITIVE STUDY OF THE HEMODYNAMIC CONDITION OF PATIENTS DURING GENERAL ANAESTHESIA WITH HALO THANE AND FENTANYL ( WITHOUT USE OF N20)

Nitrous oxide is one of the most common inhalational anesthetics in current anesthesiological practice. This gas has many side effects. Hypoxia, particularly "diffusion hypoxia" and diffusion into air-containing cavities within the body are the side effects of N2o that cause significant morbidity and even death in the patients. N2o also inactivates synthesis of methionine. The hematological, neurological, immunological and reproductive systems are affected by this unique property of N2o. Many anesthesiologists believe that the potential dangers of N2o are so great that it should no longer be used for routine clinical anesthesia. Because of the analgesic effect of fentanyl, a short acting synthetic opioid; it may he used instead of N20 . Our study was a clinical trial study and included 120 patients in two groups. In both the groups, induction of anesthesia was the same with thiopental sodium + fentanyl + pavlon and the trachea was intubated. Maintenance of anesthesia in group " N2o " was with oxygen + Halothane + N2o and in group "fentanyl" with oxygen + Halothane + fentanyl (o.5 mg/kg 1.2hr) .Blood pressure and pulse rate of patients were measured and recorded before, during, and after the anesthesia. The results were analyzed with K square, Z and t.tests. Blood pressure and pulse rate before, during and after anesthesia were the same in the two groups. These Hemodynamic measurements in the recovery room were not significantly different in the two groups. According to our finding it was concluded that: It is possible to use fentanyl [0.5 mcg/kg/1.2 hr], instead of N2o for the maintenance of anesthesia. With this dose, the hemodynamic conditions of the patients are stable during general anesthesia and recovery. More researches are needed to study the efectivity of dosages lower than 0.5 mcg/kg/30 min.