اثر فلوكستين بر اختلال پيش فعالي - كم توجهي : يك بررسي مقدماتي

The Effects of Fluoxetine on Attention-Deficit Hyperactivity Disorder (ADHD): A Pilot Study

Introduction: This study was aimed to determine the efficacy of fluoxetine in treating attention-deficit hyperactivity disorder (ADHD) in children and adolescents. Method: Twenty-two children and adolescents (6-16 years) diagnosed as having ADHD (excluding mental retardation, comorbid disorders, using concomitant medications) based on clinical psychiatric evaluation, Diagnostic Interview for Children and Adolescents (DICA), and Diagnostic and Statistical Manual of Mental Disorders-4th Edition (DSM-IV) were enrolled in an open clinical trial in a Child and Adolescent Psychiatric Clinic, 2000-2001. Fluoxetine was prescribed 20 mg a day for 7 weeks. The efficacy was assessed before and after treatment by means of three outcome measures: Children Global Assessment Scale (CGAS), Connerʹs Parent Rating Scale (CPRS), Connersʹs Teacher Rating Scale (CTRS). The side effects were assessed using a questionnaire. Results: Moderate to robust improvement (improvement >50%) were seen in 65%. Eighty-six percent reported no side effects. Mild to moderate side effects were experienced by 14% which diminished with continuation of the medication. Conclusion: Fluoxetine is well tolerated in children and adolescents and may be an alternative medication in ADHD patients who cannot take other medications.