مقايسه كارايي تركيب فلوكستين - هالوپريدول با فلوكتين دارونما در بيماران اختلال وسواسي - جبري

Objectives: This study was designed to investigate the possibility of dopaminergic involvement in obsessive-compulsive patients (OCD). Method: This double-blind study compared the efficacy of fluoxetine-haloperidol with that of fluoxetine-placebo in two groups, each comprised of 12 subjects. These subjects with obsessive-compulsive disorders were selected on the basis of DSM-IV diagnostic criteria; they were assessed by a demographic questionnaire and Yale-Brown Scale for evaluating obsessive-compulsive disorders. Findings: The results showed that the response to treatment in fluoxetine-haloperidol group was somewhat better than the Fluoxetine - placebo group from the first week of the study. The difference was significant at the third visit (end of fourth week). Results: In addition to serotonin neurotransmitter system, dopaminergic system may play a role in pathophysiology of obsessive-compulsive disorder.