مرکز منطقه ای اطلاع رساني علوم و فناوري - بررسي رابطه ي سطح خوني سرب با پرفشاري خون

چكيده لاتين :

Background: High blood pressure is the most common cardiovascular disease and is a risk factor in many cardiovascular diseases. Many factors including air pollutants are involved in high blood pressure. Lead, as an environmental pollutant, has been shown to cause hypertension in experimental studies. The aim of this study was to find out the relationship between blood lead level and hypertension. Therefore, the present study was carried out on individuals who had a high blood pressure and referred to Tehran Shariati Hospital in 2002. Materials and Methods: In this analytical case- control study 80 hypertensive patients and 80 healthy individuals were chosen as case and control groups respectively. All the members of the experimental group had a history of hypertension over 140/90 mmHg and anti-hypertensive drug use. None of the subjects had a history of renal, pulmonary or systemic diseases. Also none of them were smoker. After necessary preparations, venous blood samples were collected and the blood lead was measured by atomic absorption spectroscopy. The outcome was studied by variance analysis and Told test. Results: The results showed that the blood lead level of the study group was in the range of zero to 16.5 µg/dl and the mean was 3.8pg/dl. The analysis of mean blood lead concentration showed significant difference (P<0.0001) between hypertensive patients (5.1±0.4µg/dl) and normotensive group (2.7±0.31ig/d1). Comparison of blood lead level in hypertensive men (5.6±0.6p.g/dl) and normotensive men (3-0±3pg/dl) also showed a significant difference (P<0.0001). Likewise, comparison of blood lead level in hypertensive women (4.8±0.6) and normotensive women (2.3±(.5) showed a significant difference (P<0.0001). Comparison of blood lead level in different age groups (40-59 years) also showed a difference among hypertensive patients and normotensive group (P<0,01). But there was no significant difference between the 60-70 year-old subjects in both groups. Conclusion: The results indicate that elevation of lead concentration in blood probably increases the risk of hypertension. The risk increases when blood lead level is in the range of 5.7±1.2 p.g/dl. However, further studies with larger groups are sample is recommended.