ميزان عود و عوامل پيش گويي كننده ي آن در سرطان سطحي مثانه در بيماران بيمارستان شهيد فقيهي شيراز طي سالهاي 80-1377

Recurrence rate and prognostic factors of superficial bladder cancer in -Shiraz Shahid Faghihi hospital during the years 1998-2001

Background: Bladder cancer is the Sixth most common cancer in the world. More than 90% of the bladder cancers are transitional cell carcinoma type and 80% of superficial tumors recur after treatment. In order to determine the recurrence rate and prognostic factors of superficial bladder cancer (SBC), this study was conducted. Materials and Methods: The information of this historical cohort study was obtained from files of the patients admitted to Shiraz Shahid Faghihi Hospital in 1998-2001. The 76 cases of bladder cancer were diagnosed for the first time as new cases. Variables included in the analysis were age, sex, residential place, job, tumor pathologic grade and stage, BCG therapy, date of diagnosis and time of recurrence. All data were analysed by SPSS-10 software. For assessing prognostic factors of recurrence, the Cox regression multivariate analysis was used and the survival curves were analysed by Kaplan Mayer procedure. Results: Out of 76 cases of bladder cancer, 72 cases (94.74%) had transitional cell carcinoma and the ratio of male to female was 4.5:1. Twenty seven (45%) of all SBC cases experienced recurrence. The mean length of follow up was 14.8 months. In Kaplan-Mayer survival analysis, the mean length of recurrence free period with 95% confidence interval was 24.2 months( 18.3- 30.1). For every 10 years of age, the probability of SBC recurrence will increase about 0.5 fold. Also, the probability of recurrence in grade H and III patients was 4.5 and 11 fold higher than grade I patients, respectively. Conclusion: Considering the differences between our results and others, we suggest further regional studies to be conducted in this context in order to predict precisely the patientʹs status.