پيش بيني محلوليت بنزوديازپينها در سيستم هاي حلال دوگانه با استفاده از معاملات كلي كوسولوانسي

The estimation of benzodiazepineʹs solibility in the binary solvent mixtures by use of the general cosolvency models

The aim of the present study wase to investigate the predictability and accuracy of general cosolvency equations for estimation of benzodiazepineʹs solubility in binary solvent mixtures. The general equations were used du to the similarities between chemical structures of these drugs. The four benzodiazepines (BZPs) including diazepam, lorazepam, clonazepam, chlordiazepoxide and three water-cosolvent binary mixtures (water-ethanol, water-propylene glycol and water-polyethylene glycol 200) were selected. The mole fraction solubilities were fitted to the selected cosolvency models (equations having Xa and Xb) namely modified extended Hildebrand solubility approach (M-EHS), excess free energy (EFE), combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K) and linear double log-log (LDL-L) as general equations. Data fitting process performed by use of SPSS software (version 10.02) and iteration method. The equations compared based on the percent overall avarage errors (OAE%), the percent best adherence (BA%) and the percent mean deviations (MD%). The results showed that the EFE model was the best in predicting the solubility of benzodiazepines in binary solvent mixtures (OAE% =11.19, BA% = 41.67 and MD% = 3.88).