بررسي ارزش تشخيصي تعداد نقاط سازمان دهنده هسته اي در تومورهاي غدد بزاقي

Diagnostic valne of Nucleolar Organizer Regions (NORs) in salivary gland tumors

Background: Several diagnostic methods are being employed to detect bening and malignant lesions. One of which is silver nitrate staining for nuclcolar organizer regions (NORs). Researches have shown such regions as being useful in comparison of the tumors for detemination of changes. Aim: This study was designed to evaluate NROs as determinant for malignancy in salivany gland lumors. Material and Methods: A silver colloid technique was applied on paraffin sections of 12 cases of pleomorphic adenoma, 12 cases of Mucoepidermoid carcinoma and 12 Adenoid cystic carcinoma. A group of 12 specimens were selected with normal salivary gland tissue. Results: AgNORs were seen in 1.69±0.19 percent of the cases in normal tissue, 1.71±0.15 in pleomorphic adenoma, 2.18±o.94 in mucoepidermoid carcinoma and 2.61±0.45 in adenoid cystic carcinoma. Statistically significant differences were seen in AgNORs numbers between mucoepidermoid carcinoma and adenoid cystic carcinoma with pleomorphic adenoma and normal tissue (P<1/0001) similar results were seen between the different histologic pattern in adenoid cystic carcinoma and pleomorphic adenoma (P<0/05). Conclusion: The silver nitrate staining for nuclealar organizer (NORs) is a useful method for detection of malignant salivary gland tumors.