مرکز منطقه ای اطلاع رساني علوم و فناوري - بررسي اثر دكساپرام در متوقف نمودن لرز در مرحله بيداري از بيهوشي

چكيده لاتين :

Background and Objectives: Shivering is one of the complications usually seen after general anesthesia with volatile anesthetics including halotane. Shivering increases oxygen consumption and makes heart to work five to ten folds more when it becomes severe. In addition to increasing intraocular and intracranial pressure, it aggravates wound pain by stretching incisions too. The aim of this study was to present a pharmacological approach having least side effects and which could lessen or stop shivering during recovery phase after general anesthesia. Materials and Methods: This was an applied, double blind study performed in Nikoukari hospital to evaluate the effect of doxapram on cessation of shivering after general anesthesia in recovery room. Fifty patients were randomly selected and divided into two groups: lmg/kg doxapram was administered to the patients of group I and to the patients of control group (group II) only normal saline was administered. Data was collected using a questionnaire. Results of this study were analyzed using Studentʹs t-test. Results: Results of this study revealed that 64%of patients were males and 36% were females. Average age of patients was 50 years old and average body weight was 62 kg. When shivering began, axillary body temperature was 35.98°C and 36.01^C in doxapram and normal saline group respectively. Mean period of shivering in group I was 2.63 minutes, while it was 10.34 minutes for placebo group (p<0.005). Conclusion: Shivering is a severe and dangerous complication since it increases oxygen consumption about one hundred percent. Shivering always needs administration of additional oxygen and if it persists acid-base balance and hemodynamic status deteriorates. If shivering could be stopped, patients will have a very smooth and calm recovery period, and they can be free of many complications related to anesthesia.