مقايسه پاسخ به هورمون رشد در دو گروه كودك

A study Comparing Response to Growth hormone in two groups of children

Background and purpose : Growth hormone deficiency is the reason of growth disorder in children. Therapeutic response is related to the factors such as, age, drug dosage, numbers of administrations and duration of therapy. Researches have been done to clarify the relationship between therapeutic response with the maximum amount of GH secretion in stimulatory tests. In order to study this relationship, a research was conducted in Boali endocrine clinic on referred patients. in 1997-1990. Materials and Methods : This study was an open clinical trial done on two groups of children with growth hormone deficienes. The patients were divided in two groups of A and B on the basis of maximum amount of growth hormone secretion on stimulatory tests. Group A included I I patients, with maximum secretion of not more than 5 ng/ml_ Group B. included 5 patients with maximum secretion of more than 5 ng/ml. Patients were matched for numerical and skeletal age, dosago and frequency of injection per week. Standard Deviation Score(SDS) for weight, height and the rate of growth were compared. The results were compared by paired T-test in the groups and T-test between the groups. Results : The height growth, weight changes and also the growth rate in the groups were significant statistically. Weight SDS change was significant between two groups, but height and growth rate SDS changes between two groups was nor significant. Conclusion : No significant changes was observed in group A, which could be due to the less number of samples and much height growth SDS changes. Hence, further studies with more number of samples is recommended.