مروري بر مترونيدازول موضعي )EIYZOL( در پريودونتيت

The Review of Metronidazole (Elyzol) in Periodontitis

Background and Aim: There has been an increased interest on the local application of antibiotics in the gingival crevice in order to obtain higher concentration of the drug at the target site and to minimize potential systemic adverse effects during the last two decades. Local delivery of antimicrobials has been investigated as a possible method for controlling and treating periodontal disease. This article will discuss details of clinical results obtained by topical application of metronidazole (Elyzol) in the treatment of periodontal disease. Treatments with local delivery of metronidazole seems to be as effective as scaling and root planning in untreated and recall subjects. Results: Calculating the collective data from the available studies was shown the mean probing depth reduction and clinical attachment gain for scaling/root planing (SRP) and Elyzol (SRP + Elyzol) group are 0.33 mm and 0.32 nun respectively, which is greater than SRP alone. Conclusion: It is concluded that the use of local metronidazole delivery devices should be reserved for sites in the patients who fail to respond to mechanical instrumentation. Furthermore, before using local metronidazole, it is prudent to use mechanical instrumentation on the root surfaces of teeth to disrupt the subgingival biofilms and remove calculus.