بررسي ارتباط بين بيماريهاي تروفوبلاستيك حاملگي با ازدواج فاميلي و گروه خوني در دو بيمارستان الزهرا(س ) و شهيد بهشتي اصفهان

Study of the Relationship of Gestational Trophoblastic Diseases with Consanguinity and Mothersʹ Rh at Two Hospitals in Isfahan

Gestational trophobl.astic diseases (GTD) are more common in Africa and Asia, specicifically in the Middle East, than in Europe and America for rather unknown reasons. We do not have enough relevant information in our country including Isfahan. This study is conducted to fill in such a gap. In this case - control study, we filled out a checklist for every GTD patient hospitalized at one of the two haspitals under investigation in Isfahan, Iran. Controls were randomly selected from among other patients with no history of GTD, hospitalized at the same hospital. The number of controls were three times more than cases. The obtained data were analyzed by SPSS using Chi-square test. The findings revealed no significant relationship between GTD and blood group, Rh and consangunity. A relatively significant refationship, however, was observed when we divided the patients into three groups on the basis of their degree of relation. Also, some relationship was found to exist between GTD and age, gravid and the history of abortion. In some refecences, some effects of the O- group or interaction of blood groups of parents on GTD, but no such interaction is reported to exist between Rh and GTD. In our study, we found that consangunity had no effect on GTD; however, marriage with third degree relatives is likely to partly inenease the risk of GTD. Different results may be found in related Iiterature. Therefore, further research is recommended to be conducted. On age, gravid and history of abortion, we found results similar to previous literature.