مقايسه اثربخشي و ايمني كليندامايسين و مترونيدازول خوراكي در درمان واژنيوز باكتريايي

Background and Objectives: Bacterial vaginosis is one of the most common infectious diseases affecting women. Several types of antibiotics have been used to treat. Although metronidazole has been introduced as the most effective drug, no antibiotic is completely successful in therapeutic or preventional processes. The purpose of this study was to compare the efficacy and safety of oral clindamycin and oral metronidazole in the treatment of bacterial vaginosis. Materials and Methods: Sixty women in the range of 16 or elder with bacterial vaginosis diagnosed by Amselʹs diagnostic criteria and gramʹs stain were enrolled in a randomized , double - blind study to receive either oral clindamycin 300 mg twice daily for 7 days or 500 mg of oral metranidazole twice daily for 7 days. Women with coexiting vulvovaginal candidiasis or vaginal trichomoniasis were excluded. Test of cure was repeated 7 to 14 days following treatment. Vaginal symptoms, complications, side effects and other complaints were noted. Results: There was no statistically significant difference in cure rates for oral clindamycin (93/3%) and oral metronidazole (86.6%). Adverse reactions were mild in both groups. Four patients who received clindamycin developed non - bloody diarrhea and 4 patients who received metronidazole developed symptomatic viginal candidiasis. Conclusion: We concluded that clindamycin would be a safe and effective alternative to metronidazole for treatment of women with bacterial vaginosis.