كليدواژه :
VIII آنتي بادي فاكتور , Antibody Factor VIII , اكيموز , Intramuscular hematoma , هماتوم داخل عضله , Ecchymosis , پزشكي
چكيده لاتين :
Presence of inhibitor to factor VIII (FVIII) is a rare occurrence. The incidence of acquired inhibitors in the population is 0.2-1 per million/year and majority of such patients are older than 60 years. Presence of these antibodies is observed sometimes in association with an autoimmune disorder, hematological and nonhematologic malignancies, pregnancy,drug usage, infection and or idiopathy. Patients commonly present with hemorrhage into soft tissue ecchymosis, overt bleeding after trauma or surgery. Laboratory tests shows prolonged partial thromboplastin time (PTT), decreased level of factor VIIIand increased level of factorVIII inhibitors. These patients are treated with prednisolone and cyclophosphamide. Hereby, we report a 75 years old man with ecchymosis and swelling of left knee, prolonged PTT, decreased FVIII level and increased FVIII inhibitor. He was treated with prednisolone and was followed up for any compliant or symptoms.He improved symptomatically within 15 days. After one month, he had no symptoms of disorder and normal PTT. However, after discontinuation of prednisolone, PTT level raised again and cyclophosphamide was prescribed. PTT was normal after one month.
