كليدواژه :
Fatty liver , Asymptomatic carriers , chronic hepatitis , HBV , كبد چرب , پزشكي , ويروسهپاتيت}B {
چكيده لاتين :
Introduction: Liver steatosis causes progression in liver damage and accelerates liver fibrosis.
There is lack of data in Iran regarding the prevalence and risk factors of fatty liver in carriers of
HBV. The current study was performed to assess the prevalence and risk factors of fatty liver in
carriers of HBV in Iran. Material and methods: This study was conducted between 1995 and 2006,
as a cross sectional study, on 1120 asymptomatic HBV carriers, selected from the hepatitis clinic
of the Tehran Blood Transfusion Organization. Age, sex, marital status and paraclinacal data
including CBC, LFT, PT, lipid profile, FBS, and alcohol consumption were recorded using a
checklist. Results: Fatty liver, found in 106 subjects, showed a significant correlation with sex
(p=O.OOl), job (p-0.01), cigarette smoking (p=0.009), and previous history of liver disease (p=0.007);
liver disease also had a significant correlation with Hg levels (p=O.OOl), AST (p=O.OOl), ALT
(p=O.OOl), total bilirubin (p=0.004), direct bilirubin (p=0.032), and TG (p=0.002). FBS and total
cholesterol levels were not significantly correlated with fatty liver (p>0.05). Conclusion: Fatty liver
is seen in 10% of asymptomatic HBV carriers; considering the negative impact of fatty liver on liver
damage, it is essential to screen HBV carriers for the presence of fatty liver. Male, smokers, and
those with disturbances in lipid profile are at a higher risk.
