بررسي تاثير سير (گارسين‌) بر پارامترهاي بيوشيميايي سرم خون بز

The effect of garlic (Garcin) administration on serum biochemical factors in goats

To clarify the effect of dose and time following Allium sativum administration in goats, 16 mixed breed goats were divided into four equal groups. 4 goats were determined as the control group and the three remaining groups received different doses (9.6, 38.4, 153.6 g/animal) of garlic (Garcin), orally. All animals were bled 24 hours following garlic administration and different serum biochemical factors (total protein, albumin, globulin, glucose, BUN, creatinin, cholesterol, triglyceride, total lipid, calcium, phosphorus, AST, ALT and GGT) were measured, using conventional methods. Thereafter, the animals were given a 2-week resting period and the effect of a single dose of garlic (45 g/animal) on biochemical factors was tested on 5 goats during a-five-consecutive-day period. The results showed that different doses of garlic significantly reduced cholesterol, triglyceride and total lipid levels (p<0.05). This effect was dose dependent. A single oral dose (45 g/animal) of garlic reduced the level of serum cholesterol, triglyceride and total lipid to a minimum level on day 1. Serum creatinin decreased significantly on day 2 following garlic administration (p< 0.05). Garlic produced a time and dose dependant effect on serum lipid profile in goats.