بررسي اثر محلول موضعي سولفات روي در پيشگيري از عفونتهاي مراجعه هرپس سيمپلكس

Efficacy of topical zinc sulfate solution in prevention of recurrent herpes simplex infections.

Background and Aim : More than 85% of world population are infected with herpes simplex virus. From unique characteristics of this virus is disability of eradication of it after infection. Until now multiple method have been examined for treatment and prevention of recurrent episodes and itʹs complications, but finding of more effective , low cost and available way with few adverse reaction is considered by researchers. Materials and Methods : In this prospective clinical trial 40 patients with recurrent herpes simplex infection ( more than three times episodes per year ) treated with 0.05% zinc sulfate solution once daily for 5-10 minutes during episodes and then once per week until at least one month after recovery . Then patients followed up for six months later and in each follow up visit evaluated for characteristics such as frequency , duration of episodes and change in severity of lesions . Results : Evaluation of therapeutic response of the patients in three consecutive follow up visit in first, 3th and 6th month after ending of treatment showed significant effectiveness of this drug on reduction of frequency ( p=0.0002 ) , reduction of severity ( p=0.02) but no significant change on duration of recurrent herpes simplex episodes was showed. Conclusion : Zinc sulfate solution is an effective , available and low cost treatment but with delayed effects in prevention of recurrent herpes simplex episodes .