مقايسه اثرات محافظتي سديم متيل پارابن و بنزوات سديم بر عليه استافيلوكوك اريوس ، اشرشياكلي ، پسودوموناس ايروژينوزا در سوسپانسيون خوراكي آموكسي سيلين

COMPARISON OF PRESERVATIVE ACTIVITY OF Na BENZOAT AND Na METHYL PARABEN ON STAPHYLOCOCCUS AUREUS, E. COLI AND PSEUDOMONAS AEROGINOSA IN ORAL SUSPENSION OF PENCILLIN

Amoxicillin suspension is often prescribed for children, considering that multidose preparation contains a noticeable amount of sugar and other nutritient ingredients, which are suitable for growth and multiplication of all microorganisms. Therefore these preparations must be protected from microbial contamination by using an effective preservative system with suitable concentration. In this study the protective activities of Na Benzoate and Na Methyl Paraben assessed by standard methods of U.S.P and B.P. Results showed that Amoxicillin suspension is capable for killing of bacteries without the presence of any kind of preservative agent, but it did not confer any antifungal activity, therefore it should be protected against Candida Albicans and Aspergillus Niger by using efficient preservative. In addition in this study it was impossible to assess antibacterial activity of Na Methyl Paraben, in presence of Amoxicillin.