مطالعه مشخصات جنسي و سني فلج دوره اي با كاهش پتاسيم و تغييرات Creatine kinase سرم

The Study of Hypokalemic Periodic Paralysis Manifestations with Reference to Sex, Age and Changes of Serum Creatine Kinase

Background and Objectives: The aim of this study was to determine the age and sex, etiology and clinical manifestations of hypokalemic periodic paralysis (Hokpp) in the patients. The serum le\el of creatine kinase, a muscle enzyme was also measured. Materials and Methods: This prospective study was conducted on 40 Hokpp patients hospitalized in Neurology ward and ICU of Imam Khomeini Hospital from Sep. 1998 to year 2000. These patients were carefully examined and all laboratory tests were performed including serum creatine kinase, necessary for evaluation of hypokalemia . Results: Of the total patients studied, 97.5% of them were males and most patients (80%) were in third and fourth decade of age. Primary Hokpp was observed in 31 (77.5%) patients. 8 (20%) patients had hyperthyroidism and one of them (2.5%) had Renal Tubular Acidosis (RTA). On admission 32(80%) patients were quadriparetic and the rare syndrome of "dropped head" was seen in 4 (10%) patients. Serum creatine kinase (CK) level which was measured in 27 patients was high in 14 (52.5%) cases. Conclusion: Hokpp was most common in males as compared to females and older people were more affected. Male sex ratio and age of onset along with CK level in our patients were higher in comparison with the results of similar studies reported elsewhere.