بررسي سرعت هدايت عصبي بيماران مبتلا به لوسمي لنفوسيتي حاد، قبل و بعد از دريافت وين كريستين

A Study of Nerve Conduction Velocity in Patients with Acute Lymphocytic Leukemia (ALL) before and after Vincristine Therapy

Background and Objectives: Vincristine is an essential medication that is most commonly used in treatment of acute lymphocytic leukaemia. The major limiting factor for administration of vincristine is neurotoxicity. No agent capable of providing significant protection against vincristine neurotoxicity is available at present. The only way to reduce this side effect is modification of dosage or cessation of it. Thus , correct and early diagnosis of neuropathy and timely decision for declining or discontinuing treatment are most important. Determining the conduction velocity is one of the procedures that enables the physician for detection of neuropathy. Materials and Methods: For assessment and comparison of nerve conduction velocity before and after vincristine therapy, fifteen acute lymphocytic leukaemia patients were selected and studied. Results: A meaningful difference was observed in upper limb nerves conduction velocities before and after treatment and correlation index was found significant (p<0.05). Conclusion: The results showed that the motor and sensory nerve conduction velocities decreases following vincristine therapy.