بررسي اثر درماني سيكلوفسفاميد بر آسيب ديررس ريوي ناشي از گاز خردل در موش سوري

Evaluation of therapeutic effect of cyclophosphamide on delayed pulmonary complication of sulfur mustard in mic

Among late disorders of sulfur mustard (SM), respiratory problems especially chronic bronchitis and pulmonary fibrosis are the greatest causes of long-term disability. Cyclophosphamide has anti-inflammatory effects and It is used for some pulmonary disorders. Therefore we decided to study the therapeutic effects of cyclophosphamide in mice and the role of oxidative stress in its mechanism. One month after inhaled SM exposure, six mice were selected as positive control, six mice were treated by cyclophosphamide and eight without any SM exposure were selected as negative control. After sacrificing and sampling, biochemical indexes of chronic inflammation and pulmonary fibrosis of experimental group were compared with positive and negative control groups. Significant decrease was seen in alveolar space percentage, serum vitamin C." and SerUI11 H-O. concentration in comparison with negative control. There was an increase in hydroxylproline concentration and lymphocyte infiltration in positive control group in comparison with the negative control. Vitamin C and serum H202 concentration was increased and hydroxylproline concentration and lymphocyte infiltration were decreased in the cyclophosphamide treated group in comparison with positive control group. It seems that Cyclophosphamide has therapeutic effects on delayed lung complications of SM injury and reduction in oxidative stress can be one of the mechanisms of this drug.