بررسي اثر ضدافسردگي عصاره هيدروالكلي ريشة گياه آدمك (Biebersteinia multifida DC) در موش سوري نر

Antidepressant-like effect of Biebersteinia multifidia DC. root extract in mice

Depression is a common psychological disorder and recent data confirm the high prevalence of the disease in the world. So far, antidepressant effects of many plants have been evaluated and some are accepted in clinic. In the present research, the antidepressant effect of Biebersteinia multifida DC. root extract was studied and compared with Fluoxetine in mice, using Forced swimming ,tail suspension and open-Field tests. The anti-inflammatory and analgesic activity of the root extract have been studied, before. Oral administration (Gavage) of the root extract (4, 7 and lOmg/kg) after 1, 7 and 14 days, like Fluoxetine, significantly reduced the immobility time in tail suspension test. Also the significant reduction in immobility was observed by 4mg/kg of the root extract and Fluoxetine, after 1 and 7 days as compared with the control group. Therefore, it is possible that the antidepressant effect of root extract is induced by the variation of monoamines (especially serotonine) release in central nervous system. However, further studies are needed to highlight the exact antidepressant mechanism of Biebersteinia multifida root extract.