اثر عصارة اتانلي برگ ترة خوراكي (Allium porrum L.) بر سطح گلوكز و انسولين موش هاي كوچك آزمايشگاهي سالم و ديابتي

Effect of ethanolic extract of Allium porrum L. leaves on serum glucose and insulin levels in healthy and diabetic NMARI mice

In present study, effect of the ethanolic extract of the Allium porrum L. (Leek) leaves on serum glucose and insulin levels was investigated in both normal and streptozotocin-induced diabetic NMARI mice. The animals were made diabetic using by streptozotocin (60 mg/kg, i.p.). The ethanolic extract at doses 100, 200, 250 and 300 mg / kg, i.p. were administered for 14 days intraperitoneally. Blood samples were obtained from heart after 14 days. The groups of normal and diabetic mice were administered water as control groups. Serum glucose and insulin were measured by glucose oxidase and radioimmunoassay methods, respectively. The results showed that the ethanolic extract of leek significantly reduced the serum glucose in streptozotocin-induced diabetic mice. Also, the ethanolic extract increased serum insulin in diabetic mice. The significant compound of leek is unknown yet. The present data indicates that extract of leek has hypoglycaemic effect on diabetic animals by releasing insulin from pancreas. So, this plant should be considered in future therapeutic researches.