بررسي اثر ضد دردي عصاره هيدرو الكي درمنه در موش صحرايي نر در دو مدل درد حاد و مزمن

The study of analgesic effect of hydroalcoholic extract of Artemisia herba alba in acute and chronic models of pain in male rats

Backround and Aim: In the present time, analgesic and anti-inflammatory drugs such as nonseroidal anti-inflammatory drugs and opioid compounds are used for the releif of pain, but due to their side effects and economical issues, the significance of research on finding analgesic drugs with less side effects and their ability to substitute these synthetic drugs and substituting newer analgesic compounds is obvious. There is very little information about physiologic effects of Artemisia herba alba, one of species of Herba alba family. In the present study the possible analgesic effects of hydroalcoholic extract of this plant were investigated in chemical and thermal models of nociception in rats. Material and Methods: In this experimental study, percolation method was used for extraction. Specified amounts of dried extract were dissolved in twin to produce desired concentration. The extract were used orally or injected intraperitoneally and analgesic activity was assessed with two methods, Tail flick and Formalin test. In addition, anti nociceptive effect of this plant was compared with sodium salicylate as standard drug. Results: The plant extract significantly increased tail flick latency in tail flick test and decreased significantly pain perception in both phases of formalin test. The antinociception effect of herba alba was dose dependent. Conclusion: These data confirm peripheral and central antianalgesic effect of this plant