تغييرات تستهاي آزمايشگاهي در بيماران سيروز كبدي

Laboratory Test Abnormalities in Patients with Liver Cirrhosis

Introduction and Objective: Cirrhosis is a pathologically defined condition, which is characterized by a combination of two main lesions, fibrosis and regeneration nodules along with a spectrum of clinical manifestations. In patients with liver cirrhosis, hepatocyte damage and necrosis can lead to abnormalities In laboratory tests and liver function The current study was performed in order to evaluate such abnormalities in these patients Materials and MethodS: Subjects of the study consisted of 55 HBs-Antigen negative patients (27 males and 28 females) who were selected during 2 years. Five ml blood sample was collected from each patient for measurement of liver enzymes, bilirubin, hemoglobin, blood proteins level and prothrombine time by routine diagnostic laboratory tests Results: In these patients the mean of liver enzymes level and serum globulin were higher than normal range, and hemoglobin concentration and serum albumin level were lower than normal range but the prothrombine time was prolonged. Raising liver enzyme was lower in aged patients than in young ones. Level of serum albumin decreased and serum globulin increased in aged patients. Conclusion: Results of the study showed, many abnormalities in laboratory tests in patients with liver Cirrhosis which, in turn, can cause many complications in these patients. Thus serial laboratory tests are important for rapid diaqnosis the management and prevention of these complications in patients with liver cirrhosis.