عنوان مقاله :
بررسي شيوع هفت آنتي بادي در زنان مبتلا به سقط مكرر مراجعه كننده به مركز فوق تخصصي درمان ناباروري و سقط مكرر ابن سينا
عنوان به زبان ديگر :
Prevalence of some antibodies in Women with recurrent abortion
attending Avicenna Infertility Clinic
پديد آورندگان :
زراعتي، حجت نويسنده دانشكده بهداشت و انستيتو تحقيقات بهداشتي-دانشگاه علوم پزشكي تهران Zeraati, H. , عارفي، سهيلا نويسنده پژوهشكده فن آوري هاي نوين پزشكي جهاد دانشگاهي ابن سينا تهران Arefi, S. , سلطان قرايي، هاله نويسنده پژوهشكده تحقيقات بيوتكنولوژِي توليدمثل-پژوهشكده فناوري هاي نوين علوم پزشكي جهاد دانشگاهي-ابن سينا، تهران Soltanghoraei, h. , آخوندي، محمدمهدي نويسنده مركز تحقيقات بيوتكنولوژِي توليد مثل-پژوهشكده فن آوريهاي نوين پزشكي جهاد دانشگاهي ابن سينا تهران Akhondi, M.A. , محمدزاده، افسانه نويسنده پژوهشكده فن آوري هاي نوين پزشكي جهاد دانشگاهي ابن سينا تهران Mohammadzadeh, A. , ذنوبي، مژده نويسنده مركز فوق تخصصي درمان ناباروري و سقط مكرر ابن سينا، جهاد دانشگاهي دانشگاه شهيد بهشتي؛ پژوهشكده فناوري هاي نوين علوم پزشكي جهاد دانشگاهي ابن سينا تهران Zonobi, M. , مدبري، يونس نويسنده مركز فوق تخصصي درمان ناباروري و سقط مكرر ابن سينا، پژوهشكده فناوري هاي نوين علوم پزشكي جهاد دانشگاهي ابن سينا تهران Modabcri Saber, Y. , بهرامي، محمدابراهيم نويسنده مركز فوق تخصصي درمان ناباروري و سقط مكرر ابن سينا، پژوهشكده فناوري هاي نوين علوم پزشكي جهاد دانشگاهي ابن سينا تهران Bahrami, M.E.
اطلاعات موجودي :
ماهنامه سال 1386
رتبه نشريه :
فاقد درجه علمي
كليدواژه :
آنتي بادي ضدهسته اي , آنتي بادي ضدكارديوليپين , Recurren t abortion , آنتي بادي ضدپراكسيدازتيروئيدي , Anti-phospholipid antibody , آنتي بادي ضدپراكسيداز تيروئيدي , Anti-cardiolipin antibody , آنتي بادي ضد تيروگوبولين , Anti-nuclear antibody , فاكتور روماتوييد , Anti-thyroglobulin antibody , آنتي بادي ضد DNAدو رشته اي , Anti-thyroid peroxidase antibody , Rheumatoid Factor , سقط مكرر , آنتي بادي ضد فسفوليپيد
چكيده لاتين :
Background: Recurrent abortion is a problem of a number of infertile couples with different
etiologies, and one of these is autoimmune defects. The prevalence of some antibodies found in the
sera of these pati ents is more than the ones found in normal women. This study has been done to show
the prevalence of antibodies in the sera of women with recurrent abortion in one of the infertility
center s in Tehran.
Methods: One-hundred and thirty seven women with two or more consecutive pregnancy losses and
without any history of autoimmune or thyroid disease or a history of thrombosis attended Avicenna
Infertility Clinic durin g 2006 and 2007. Patients with abnormal TSH or any history of autoimmune
diseases were excluded from the study, Antithyrogl obulin (Anti-TG), antithyroid peroxidase (AntiTPO),
antiphospholipid (aPL), anticardiolipin (aCL), antinuclear (ANA) and anti-d ouble -strarided
DNA (Anti-ds DNA) antibodies plus rheumatoid factor (RF) were measured in the patientsʹ sera.
Mann- Whitney and Pearson correlation tests were used to analyze the data by SPSS software.
Results: Anti-TPO was detected in 19% and anti-TG in 14.6% of the study group. Positive results of
nPL and aCL were detected in 1.56% and ANA in 1. 52% of the patients. None of the patients had dsDNA
antibodies. RF was seen in 20 out of 102 patients (19.6%). Anti-TPO and anti-TG results were
analyzed again in 77 patients with three or more consecutive pregnancy losses and no differences
were found between them and patients with two or more recurrent abortions.
Conclusion: Comparison between these results and published results of other papers showed a lower
prevalence of the mentioned antibodies in Iran, which could be due to different factors: 1- If a
complete history of the patientʹ s background diseases is taken, possibility of positive results for aPL,
aCL, ANA and ds DNA will be decreased. 2- More research on Iranian patients is needed 3Differences
in kits and Iraniansʹ normal ranges are possible, RF needs to be more investigated. More
studies on anti-TPO and anti-TG with control groups are suggested.
عنوان نشريه :
مجله دانشكده پزشكي دانشگاه علوم پزشكي تهران
عنوان نشريه :
مجله دانشكده پزشكي دانشگاه علوم پزشكي تهران
اطلاعات موجودي :
ماهنامه با شماره پیاپی سال 1386
كلمات كليدي :
#تست#آزمون###امتحان
