مطالعه اثر داروي بيهوشي عمومي پروپوفول بر تغييرات بيوشيميايي سرم در مرغ بومي

Studying of Propofolʹs effects-induced general anesthesia on biochemical changes of serum in domestic hen

Propofol is a short-acting intravenous general anesthetic for induction and maintenance of general anesthesia. Propofol used alone or in combination with other eNS depressant drugs in human and animals. Nowadays studies considering usage of anesthetic drugs in poultries for research and surgery purpose are in developing. Injectable drugs have problems in poultry, so inhalant anesthetic drugs are preferred. But sometimes inhalant anesthetic drugs have problems too. In this experimental study, we evaluate serum biochemical change subsequent propofol-indueed general anesthesia in adult aborigine hen. Therefore 10 adult aborigine hens selected randomly. To induce anesthesia propofol O.5mg/kg) injected intravenously and for maintenance propofol (0.5mglkg/min) infused until 90 minute with infusion pump. During anesthesia the following biochemical factors were determined in 0, l5, 30, 60, 90 minutes and 24, 72 hours after anesthesia. Serum albumin, alanine amino transferase (ALT), aspartate amino transferase CAST), alkaline phosphates (ALP), bilirubin, blood urea nitrogen (BUN) and creatinine concentration were measured. Results showed that: bilirubin, BUN, ALP and creatinine concentrations significantly changed (p<0.05), but ALT, AST and albumin concentration had none significantly changed. Using this drug in poultryʹs anesthesia and surgery needs to be investigated more.