ايمونوفنوتايپ اطفال مبتلا به لوسمي حاد لنفوبلاستيك، مراجعه كننده به بيمارستان شهيد صدوقي يزد

Evalution of Immunophenotype in Children with Acut Lymphoblastic Leukemia Admitted to Shahid Sadoughi Hospital, Yazd

Introduction: Immunophcnotype is an important factor for determining the mode of treatment in acute lymphoblastic leukemia. The aim of this study was to determine distribution rate of ALL phenotypes by flowcytomerry. Methods This observational study was conducted by a case series method. The study population included children (0-1467) with ALL admitted to Shahid Sadoughi hospital. In order to determine the CD markers, bone marrow aspiration samples of 56 patient were sent to the flowcvtornetry center of Yazd Blood Transfusion Center. According to the percentage of CD markers. the groups and subgroup of leukemic cells were determined and the relation between prognostic factors with the type of leukemic cells (T- cell. B-cell) was analyzed by using statistical tests. Results According to flowcytornetry results, 31 patient (59.6%) had T-cell immunophenotypc and 21 patient (40.4%) had B-cell immunophenotype. In this study, although the frequency of undesirable prognostic factors in T-cell group was more than B-cell ALL, the difference was significant only for tbe male patients (p: 002). Conclusion, Prevalence ofT- cell in our population is greater than other parts of the world that may be due to environmental factors including carcinogenic agents. There was 110 significant difference between the out come or the two group (B-cell and T-cell), which can be due to the selection of the type of chemical therapy based on risk factors.