خالص سازي و رنگزدايي گليسريزين استخراج شده از عصاره شيرين بيان براي مصارف دارويي

Purification and decolorization of extracted clycyrrhizin from licorice root for pharmaceutical applications

Licorice is a self-prop elling plant that has many applications in pharmaceutical andfood industries. Glycyrrhiza Glabra is a kind of licorice whose main active compo nent is a triterpenoid saponin named gly cyrrhizin. After extraction, acid precipitation used for preliminary isolation and concentration. Flavonoids are found as pigment in the aqueous extracted product. Decolorization of this extract is one of the major problem. Adsorption with activated carbon was used considering operational parameters including pH, temperatur e and agitation. Finally, decolorized extract was purified by crystallization in aqueous ethanol at different pH and ethanol percentage to y ield the final purified produ ct. Results show that the best pHfo r precipitation is about 2. Norit Activated Carbon is found to be the good choice fo r adsorp tion by 64%yi eld and 68% purity in industry. Crystallization can purify the extrac t by 90% aqu eous ethanol at pH 13 to result in a product of 98.2% purity. In this case, however, the production output decreased to 65%.