تاثير تمرينات استقامتي بر برخي از شاخص هاي دستگاه هموستازي و چربي هاي خون موش هاي صحرايي ماده مسن

The effects ofendurance training on some indices ofhaemostatic system and blood lipids in the aged female rats

The purpose ofthe present study was to determine the effects of12 weeks endurance training on some indices ofhaemostatic system and blood lipids in WistarJ4848 rats with the weight of 325.6 ± 4.93 gr and age of 21 months that had passed their fertility period at least for 3 months. For this purpose, forty rats were divided randomly into control and experimental groups and the subgroups ofmid-test and post-test. After two weeks offamiliarization the training group performed 12 weeks of running on treadmill five days a week at the progressive speed and duration. Blood samples were taken following 12-14 hours overnight fasting at three stages before-, mid-, and post-training The fibrinogen, activated partial thromboplastin time (APTT) and blood lipids (HDL-C and LDL-C) concentrations were measured by clotting and enzymatic methods, respectively. Data were analyzed by using twol-lay ANOVA with repeated measures and independent t-student tests. The results showed that fibrinogen and APTTlevels after endurance training, respectively, were decreased and increased significantly after 6th and 12th weeks oftraining and in comparison with control group. In the other hand, total cholesterol changes were insignificant following the 6th and 12th weeks. However, vel)ʹ low density lipoprotein level was only significant after 12 weeks. Data analysis for blood lipids (VLDL-C LDL-C JfDL-C .TC ,TG .TCI HDL-C J LDL-CIHDL-C) revealed significant changes in training group after 6 and 12 weeks in comparison with control. The findings of the present study suggest that endurance training of moderate intensity induced adaptations that can improve the haemostatic system and prevent the process ofthrombusformation