مقايسه اثر تزريق داخل ضايعه مخلوط گلوكانتيم و استروئيد با گلوكانتيم در درمان ليشمانيوز پوستي

Comparison between intralesional Glucantime plus steroid and Glucantime in thetreatment of cutaneous leishmaniasis

Introduction: Cutaneous leishmaniasis is a parasitic disease caused by various Leishmaniasis species and can result in a disfiguring scar. Hence, effective treatment is mandatory fur prevention of the disease sequellae. The goal of this study was assessment and comparison of inrralesional Glucantime plus steroid with intralesional Glucantime in the treatment of cutaneous leishmaniasis. Methods: In this clinical trial stndy , 62 patients with cutaneou s leishmaniasis were divided randomly into 2 groups . 32 cases were treated with Glucamime pluse steroid while other 30 received only Olucaruirne, In Glucantime plus steroid group, 0.5 cc/cmʹ Glucantime (48.5 mgr) plus 0.1 cc/cmʹ Triamcinolone Acetonidc (4 rngr) were injected intradermally, whereas in the other group , Glucantime (48.5 mgr) was injected intradermall y. Six courses of injection was applied weekly. After Fulfilling treatment, the lesions were evaluated for size, erythema and induration. Data was analyzed by t-test and differences were considered significant with P <0.05. Results: Clinical improvement mean scores were 5.6 (62%) and 5.2 (57%) after 6 weeks in the Glucantirne plus steroid and Glucantime alone groups , respectively. The difference was not statistically significant. More sarisfaetory results and higher scores were noted in lesions with less than 4 months duration in compari son with lesions of longer than 4 months in Glucantirne plus steroid group. Conclusion: Both treatment modalitie s are not considerably different in total, but in lesion s with less than 4 month s duration. the difference is noticeable, obvious which might be the consequence of diminished edema, erythema and induration following stero id therapy .