ارتباط بين سطح سرمي و بزاقي هورمون كورتيزول

Evaluation ofthe Level ofSalivary and Serum Cortisol

In spite or its convenience. and inexpensiveness, measurement of salivary cortisol has nOI gained widespread popularity. Indeed. even though its usefulness in the assessment of activity of hypothalamie-pituitary-adrenal (HPA) axis has been reporte d in various clinical conditions, severa l centers are still resistant to adopting (his procedure. The aim of this study is to evaluate the correlation between salivary and serum cortisol by radioimmunoassay (RIA). Materials and Methods: This descriptive crass-sectional study carried out in September to February 2005 on 80 patients at laboratory of Ghaem Hospital of Mashhad University of Medical Sciences, A total of 42 women and 38 men aged 46±1 6,5 were studied. Paired saliva and serum samples were obtained after specialized protocols. Salivary and blood samples were collected at 8 to 9 A.M, Cortisol in saliva and total cortisol in serum were measured with a commercial radioimmunoassay (RIA), Results: Mean serum cortisol was 19.72 ± 835 and mean salivary cortisol was 0 . 1l~ ±0.07 ug/dl. , Significant linear correlation was found between salivary and serum total cortisol (r-0/35, p