مقايسه اثرات درماني اكسي بوتينين در دتروزيتول بر اختلالات ادراري در هشتاد بيمار مبتلا به مولتيپل اسكلروزيس

Effects ofOxybutynin and Detrusitol 0 11 Urinary Dysfunction ofMS Patients

Multiple Sclerosis (MS) is a chronic disease of high prevalence of central nervous system, mostly affecting young adualts especially females. Voiding dysfunction is one of its complications, diagnosis and treatment of which will be of great value in patientsʹ quality of life. In this study, frequency and type of urinary dysfunction in MS were evaluated and effects and side effects of two drugs of Oxybutynin and Detrusitol were compared. Materials and Methods: This clinical trial study was performed from July 2004 until july 2005 at Ghaem Hospital of Mashhad University of Medical Sciences on women with clinical manifestations of voiding dysfunction (ove ractive bladder). Patients were divided into two groups randomly. One group treated with Oxyburynin 5 mg bid, and the other with Detrusitol 2 mg bid, and effects and side ellcc to of these drugs were compared. Data analyzed using l. fisher ʹI-student andcochrane tests. Results: The ratio of female to male was 6 !O 1. The average age of onset was 25_X . Spastic urinary dysfunction prevalence was 61.2%. The most common symptom was urination frequency. Improvement in urinary symptoms were similar in both groups. Among observed side effects, only dry mouth was statistically more frequent in patients who used Oxybutyniu in comparison to those who used Detrusitol. Patients satisfaction was similar in both groups. There was a relationship between existence of plaques ill perivcntricular white matter and urinary dysfunction symptoms. Conclusion: According to the rate of improvement, side effects and the costs, Oxyburynin is more suitable for overactive bladder treatment.