نقش سطح سرمي تستوسترون به عنوان يك فاكتور پيشگويي كننده در پاسخ به درمان با كلوميفن در ناباروري مردان

Serum Testosterone Level as a Predictor of Response of Infertile Males to Clomiphene

Background and Purpose: Clomiphene is the most common drug for the male idiopathic infertility treatment with different results, and no valuable factor ha been suggested for prediction of treatment. Therefore, the present study was designed to investigate the relationship between early morning total Serum Testosterone Level (STL) before treatment and post-clomiphene changes in the spermogram. Methods and Materials: This clinical trial study was conducted on 172 idiopathic infertile men, from 2001 to 2006 in Mashad, Iran. Demographic and spermogram data were recorded via questionnaires, and patients were divided into 6 groups by their pre-treatment STL. Spermogram parameter changes before and after clomiphene therapy were analysed with SPSS software using t-test, ANOVA, and Fisherʹs test. Results: Mean age of patients was 31 years; and mean Serum Testosterone Level was 361.3 ngldl. After prescribing clomiphene, recovery was observed in the spermogram of in 125 patients (72.7%) with Total Serum Testosterone Level of 200-500 ngldl (P~0.031). Conclusion: Early morning Serum Testosterone Level can be used as a criterion for predicting the efficacy of clomiphene in male idiopathic infertility, .