اثر عصاره تام و فراكسيون هاي هيدرومتانولي حاصل از چاي سياه ارتودكس ايراني بر پروفايل ليپيدي رت هاي ديابتي نوع يك

The Effects of Total Extract and its Different Hydromethanole Fractions of Iranian Black Orthodox Tea on Blood Lipid Profile in Type I Diabetic Rats

Background and Objectives: Diabetes is one the most common chronic diseases in developed and developing countries, and its cardiovascular complications can be induced lipid disorders, one of the suspected mechanisms of tea consumption in prevention of cardiovascular complications is its effect on lipid pritilc. This study was aimed to examine the effect of total and different fractions of Iranian black orthodox tea on blood lipid profile in type I diabetic rats. Moteriats and Methods: This study was conducted on 56 male rats which were randomly divided in to 8 groups (7 rats in each group, the range of weight: 200 - 250 gr). Group I and 2 were non-diabetic, groups 3 - 8 Were diabetic, and diabetes was induced with intraperitoneal injection of streptozotocin (60mg/kg). Groups I to 8 was received carrier, total extract, carrier, total extract, methanol fractions of 20%,40%,60% and 80% plus 100% respectively. In the end of study blood lipid profile was measured. Data were analyzed by using one and two ways ANOVA and nested variance. Results: Triglycerid was reduced in total extract received diabetic group (p~0.045). 20% fraction of black tea significantly decreased triglyceride (p~0.004). total cholesterol (p~O.OOO) and LDL cholesterol (p~O.OOO) more than other groups. There was no significant differences between groups that received total extract and fractions according HDL cholesterol levels(p>0.05). Conclusion: It can be concluded that injection of total extract and 20% fraction of black tea had positive effect on blood lipid profile in diabetic rats. Therefore consumption of black tea might prevent cardiovascular diseases from diabetes complications.