اثر آتورواستاتين در درمان اختلال نعوظ در بيماران دچار هيپرلپيدمي

A study on the effectiveness of atorvastatin in the treatment of erectile dysfunction in hypercholesterolemic men

Objective: Hypercholesterolemia is a known risk factor for erectile dysfunction (ED). Lipid lowering agents may improve ED in hypercholesterolemic men. The aim of the present study was to evaluate the effects of lipid lowering agent atorvastatin in treatment of ED m hypercholesterolemic men. Subjects and Methods: In this prospective controlled clinical trials a total of 1hypercholesterolemic men with ED were enrolled the study. They were treated with atorvastatin (20 mg once daily for a period 4 months). All the patients were evaluated by history, clinical interview, physical examination and laboratory analysis both at the beginning and end of the study. International index of erectile function (]IEF) questionnaire and nocturnal penile tumescence testing rigidity (NPTR) tests were also performed for each patient, prior to and after the study. Results: Eleven patient were entered the study with a mean age of 54 ± 3 years, of whom 10 patients completed the study. Low density lipoprotein (LDL) decreased in a statistically significant manner after treatment period (mean difference= 39.1%, P< 0.005) in all of the patients. All the patient reported subjective improvement in erectile function (P +4.7, 95 % CI 2-8-6.2, P< 0.001). NPTR test showed statistically significant improvement in rigidity activity units (RAU) in the basal area of penis (P