اسكن FDG PET-CT در انواع لمفوم غيرهوجكين (NHL) بر اساس طبقه بندي WHO

FDG-PET/CT Scan in Different Non- Hodgkin LymhomaAccording to the World Health Organization (WHO)Classification System

Introduction: According to the World Health Organization (WHO) classification Lymphoid neoplasms are categorized into 3 major groups: Hodgkinʹs disease (HD) and the non-Hodgkinʹs lymphomas (NHl) ofB-cell or T-cell/natural killer (NK) cell origin. Few dedicated reports have heen published ahout metabolic imaging by FDG-PET CT in different subtypes of NHLaccordigto who classification.. Objeetive: Determine the reliability of FDG-PET-C Tin detection of different subtypes of NHL according to usingthe WHO classification. Materials and Methods: In a total of 164 patients with a histological proven non-Hodgkin lymphoma, FDGPET/ CT imaging was performed for staging (n~138) and restaging (n=26). FDG-uptake pattern according to different lymphoma subtypes was qualitatively evaluated Results: Distinctive FDG-uptake could reliably be seen in one site of all patients with DlBCl In~77), mediastinal large b-cell lymphoma (n=12), mantel cell lymphomamvS), PTLD (n--S), anaplastic large cell (1 cell) lymphoma (nʹ6), precursor B lymphoblastic lymphoma (ne l). plasmacytoma of sternum (n~2), splenic marginal zone Iymphomamel ), precursor t lymphoblastic lymphoma of thymus (ne l ), extranodal NKit cell NHl NASAL type (n-S), primary cutaneous anaplastic large cell (t cell) lymphoma (n~2), angioimmuoblastic t cell tymphomam-I) and Burkitt lymphoma (n~2). One ease ofsmalllymphoeytic lymphoma and one ease of Ct.l. were not deteeted by PET/CT. Evaluation of follicular lymphoma (86% positive) and MALT lymphoma (83%positive) revealedless reliableresults. Conclusion: T-cell lymphomas and most B-celllymphomas can be reliably evaluated by FDG-PET/CT imaging.